Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 13/20 | 0.37 |
| ▸ | JAK1 | P23458 | 12/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22139118 | 1.00 | PTK6 (0.42) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22139129 | 0.95 | PTK6 (0.44) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22154480 | 0.95 | PTK6 (0.44) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22139150 | 0.94 | PTK6 (0.42) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22139149 | 0.94 | PTK6 (0.42) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22139080 | 0.93 | PTK6 (0.51) | PTK6AURKBLCK | |
| SCHEMBL22153157 | 0.93 | PTK6 (0.51) | PTK6AURKBLCK | |
| SCHEMBL24910545 | 0.92 | PTK6 (0.40) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22124325 | 0.91 | PTK6 (0.46) | PTK6JAK2JAK1AURKBTTK | |
| SCHEMBL22139092 | 0.91 | PTK6 (0.45) | PTK6AURKBTTKLCKPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| WO-2020126956-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020127075-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |