SCHEMBL22143

SCHEMBL22143

Nc1nc2c(c(=O)[nH]1)=NC(=O)N=2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.42
MAPT P10636 2/20 0.38
CDK1 P06493 1/20 0.38
CDK4 P11802 1/20 0.38
CDK2 P24941 1/20 0.38
THRB P10828 2/20 0.37
MITF O75030 1/20 0.37
TP53 P04637 1/20 0.37
ALOX15 P16050 1/20 0.37
HBB P68871 1/20 0.37
HIF1A Q16665 1/20 0.37
QTRT1 Q9BXR0 1/20 0.36
DYRK1A Q13627 1/20 0.35
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 2/20 0.34
HSD17B10 Q99714 2/20 0.34
LMNA P02545 1/20 0.34
GLA P06280 1/20 0.34
PMP22 Q01453 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21805968 1.00 PNP (0.42) PNPMAPTCDK1CDK4CDK2
SCHEMBL29733326 0.98 PNP (0.41) PNPMAPTCDK1CDK4CDK2
Phosphoric Acid SCHEMBL6461187 0.91 PNP (0.36) PNPMAPTCDK1CDK4CDK2
SCHEMBL1682869 0.84 MAPT (0.68) PNPMAPTTHRBMITFTP53
SCHEMBL9154825 0.80 PNP (0.39) PNPMAPTCDK1CDK4CDK2
SCHEMBL27844165 0.77 PNP (0.37) PNPMAPTCDK1CDK4CDK2
SCHEMBL27898126 0.71 PNP (0.42) PNPMAPTCDK1CDK4CDK2
SCHEMBL7906237 0.69 PNP (0.41) PNPMAPTCDK1CDK4CDK2
SCHEMBL30776984 0.64 PNP (0.40) PNPMAPTCDK1CDK4CDK2
SCHEMBL6577465 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6938 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107204-A1 METHODS FOR ANALYZING LOW-DEPTH GENOME SEQUENCING DATA TO DETECT MINIMAL RESIDUAL DISEASE GUARDANT HEALTH, INC. (US) 2026-05-21 WO claimed
US-12630851-B2 Polynucleotide modification methods OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-05-19 US claimed
EP-4739788-A1 COMPOSITION COMPRISING MODIFIED DNA IDENTIFIER SEQUENCES FOR DNA MODIFICATION SCREENING ETH Zurich (CH) 2026-05-13 EP claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122012715-A Lock probe based on Fpg enzyme and CRISPR/Cas12a combination and used for detecting G > A mutation in gene mutation, detection kit, detection method and application thereof 西南医科大学 2026-05-12 CN claimed
US-20260117278-A1 METHOD, KITS AND SYSTEM FOR DUAL LABELING OF NUCLEIC ACIDS Chen cheng yao (TW) 2026-04-30 US claimed
EP-3824100-B1 POLYNUCLEOTIDE SYNTHESIS METHOD OXFORD NANOPORE TECH PLC (GB) 2026-04-29 EP claimed
EP-4728091-A1 CONCURRENT SEQUENCING WITH SPATIALLY SEPARATED RINGS Illumina, Inc. (US) 2026-04-22 EP claimed
US-5849480-A Process and device for assaying a hapten BIO MERIEUX (FR) 1998-12-15 US claimed
EP-0828854-A1 ANALYTICAL AND THERAPEUTIC AGENTS UNIVERSITY OF LEICESTER (GB) 1998-03-18 EP claimed
WO-1998009526-A1 ANTIOXIDANT DERIVED FROM LENTIL AND ITS PREPARATION AND USES BIOTICS RESEARCH CORPORATION (US) 1998-03-12 WO claimed
US-5665541-A Formation of triple helix complexes for the detection of double stranded DNA sequences using oligomers which comprise an 8-modified purine base THE JOHNS HOPKINS UNIVERSITY (US) 1997-09-09 US claimed
EP-0775142-A1 SUBSTITUTED O6 -BENZYLGUANINES AND 6(4)-BENZYLOXYPYRIMIDINES THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1997-05-28 EP claimed
WO-1996038588-A1 ANALYTICAL AND THERAPEUTIC AGENTS UNIVERSITY OF LEICESTER (GB) 1996-12-05 WO claimed
EP-0672171-A1 FORMATION OF TRIPLE HELIX COMPLEXES OF DOUBLE STRANDED DNA USING NUCLEOSIDE OLIGOMERS WHICH COMPRISE PURINE BASE ANALOGS THE JOHNS HOPKINS UNIVERSITY (US) 1995-09-20 EP claimed
WO-1993005180-A1 FORMATION OF TRIPLE HELIX COMPLEXES OF DOUBLE STRANDED DNA USING NUCLEOSIDE OLIGOMERS WHICH COMPRISE PURINE BASE ANALOGS THE JOHNS HOPKINS UNIVERSITY (US) 1993-03-18 WO claimed
EP-0112632-A2 Use of 8-substituted guanine derivatives in the manufacture of a medicament. SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1984-07-04 EP claimed
WO-1984001898-A1 MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINNG 8-SUBSTITUTED GUANINE DERIVATIVES SCRIPPS CLINIC RES (US) 1984-05-24 WO claimed