Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 4/20 | 1.00 |
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sr-3677 SCHEMBL453528 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL29378608 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL30373321 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL15842050 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL29249231 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562728 | 0.97 | ROCK2 (0.94) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562733 | 0.97 | ROCK2 (0.94) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562553 | 0.94 | ROCK2 (0.88) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL1987562 | 0.91 | ROCK2 (0.84) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL1990233 | 0.91 | ROCK2 (0.83) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220074923-A1 | METHODS OF IDENTIFYING PARKIN-MEDIATED MITOPHAGY ACTIVATING AGENTS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-03-10 | — | — | US | disclosed |
| WO-2020124236-A1 | METHODS OF IDENTIFYING PARKIN-MEDIATED MITOPHAGY ACTIVATING AGENTS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-06-25 | — | — | WO | disclosed |