Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 4/20 | 1.00 |
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sr-3677 SCHEMBL22145950 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL29378608 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL30373321 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL15842050 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| Sr-3677 SCHEMBL29249231 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562728 | 0.97 | ROCK2 (0.94) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562733 | 0.97 | ROCK2 (0.94) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL12562553 | 0.94 | ROCK2 (0.88) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL1987562 | 0.91 | ROCK2 (0.84) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 | |
| SCHEMBL1990233 | 0.91 | ROCK2 (0.83) | ROCK2ROCK1AKT1CDC42BPARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9943525-B2 | Composition for reducing cell senescence comprising Rho-kinase inhibitor and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2018-04-17 | — | — | US | claimed |
| EP-3006028-A1 | COMPOSITION FOR REDUCING CELL SENESCENCE COMPRISING RHO-KINASE INHIBITOR AND USE THEREOF | Samsung Electronics Co., Ltd (KR) | 2016-04-13 | — | — | EP | claimed |
| US-20160095864-A1 | COMPOSITION FOR REDUCING CELL SENESCENCE COMPRISING RHO-KINASE INHIBITOR AND USE THEREOF | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2016-04-07 | — | — | US | claimed |
| US-8883502-B2 | Expandable cell source of neuronal stem cell populations and methods for obtaining and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-11 | — | — | US | claimed |
| US-20130236436-A1 | EXPANDABLE CELL SOURCE OF NEURONAL STEM CELL POPULATIONS AND METHODS FOR OBTAINING AND USNIG THEM | ZHANG KANG (US) | 2013-09-12 | — | — | US | claimed |
| EP-4342982-A1 | METHOD FOR PRODUCING MULTINUCLEATED MEGAKARYOCYTE WITH ENHANCED PLATELET PRODUCTION CAPABILITY, METHOD FOR PRODUCING PLATELETS, METHOD FOR PRODUCING PLATELET PREPARATION, AND METHOD FOR PRODUCING BLOOD PREPARATION | Megakaryon Corporation (JP) | 2024-03-27 | — | — | EP | disclosed |
| CN-117500913-A | Method for producing multinucleated megakaryocyte having enhanced platelet production ability, method for producing platelets, method for producing platelet preparation, and method for producing blood preparation | 株式会社美加细胞 | 2024-02-02 | — | — | CN | disclosed |
| CN-110573607-B | Multipotent stem cell assay | 洋蓟治疗有限公司 | 2023-10-20 | — | — | CN | disclosed |
| US-11591571-B2 | Pluripotent stem cell assay | CYNATA THERAPEUTICS LIMITED (AU) | 2023-02-28 | — | — | US | disclosed |
| US-11548861-B2 | Drugs and compositions for the treatment of ocular disorders | Graybug Vision, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| WO-2022265117-A1 | METHOD FOR PRODUCING MULTINUCLEATED MEGAKARYOCYTE WITH ENHANCED PLATELET PRODUCTION CAPABILITY, METHOD FOR PRODUCING PLATELETS, METHOD FOR PRODUCING PLATELET PREPARATION, AND METHOD FOR PRODUCING BLOOD PREPARATION | 株式会社メガカリオン | 2022-12-22 | — | — | WO | disclosed |
| US-20220088010-A1 | Co-Administration of inhibitors to produce insulin producing gut cells | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-03-24 | — | — | US | disclosed |
| EP-2598635-B1 | CORTICOGENESIS OF HUMAN PLURIPOTENT CELLS | CAMBRIDGE ENTPR LTD (GB) | 2014-10-22 | — | — | EP | disclosed |
| US-20130236436-A1 | EXPANDABLE CELL SOURCE OF NEURONAL STEM CELL POPULATIONS AND METHODS FOR OBTAINING AND USNIG THEM | ZHANG KANG (US) | 2013-09-12 | — | — | US | disclosed |
| US-20130149287-A1 | Corticogenesis of Human Pluripotent Cells | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2013-06-13 | — | — | US | disclosed |
| WO-2012034101-A2 | EXPANDABLE CELL SOURCE OF NEURONAL STEM CELL POPULATIONS AND METHODS FOR OBTAINING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | WO | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548861-B2 | Drugs and compositions for the treatment of ocular disorders | PDE6C, PDE6A, PDE6D | ROCK2 400/4885ROCK1 197/4885AKT1 514/4885 |
| US-20220088010-A1 | Co-Administration of inhibitors to produce insulin producing gut cells | IAPP, GPR119, FOXO1 | ROCK2 18/4885ROCK1 15/4885AKT1 77/4885 |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | ROCK2 4/4885ROCK1 1/4885AKT1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.