Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.42 |
| ▸ | CASP5 | P51878 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30788620 | 1.00 | HRH4 (0.58) | HRH4CRHBPCRHR2SMN1; SMN2GBA1 | |
| SCHEMBL10377507 | 0.86 | HRH4 (0.62) | HRH4SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL1708189 | 0.86 | KMT2A (0.56) | CRHBPCRHR2SMN1; SMN2GBA1KMT2A | |
| SCHEMBL11898909 | 0.84 | KMT2A (0.68) | HRH4CRHBPCRHR2KMT2AMEN1 | |
| SCHEMBL13693076 | 0.84 | KMT2A (0.55) | CRHBPCRHR2SMN1; SMN2GBA1KMT2A | |
| SCHEMBL30296930 | 0.84 | HRH4 (0.61) | HRH4SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL1458548 | 0.84 | HRH4 (0.61) | HRH4CRHBPCRHR2SMN1; SMN2KMT2A | |
| SCHEMBL13033934 | 0.81 | KMT2A (0.56) | HRH4CRHBPCRHR2SMN1; SMN2GBA1 | |
| SCHEMBL22119420 | 0.81 | NOS3 (0.44) | HRH4GBA1KMT2AMEN1KDM4E | |
| SCHEMBL22155692 | 0.80 | KMT2A (0.42) | HRH4GBA1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510463-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2020132648-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |