Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | NOS2 | P35228 | 3/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22119420 | 0.89 | NOS3 (0.44) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL22148753 | 0.89 | KMT2A (0.51) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL31118753 | 0.83 | GBA1 (0.48) | KMT2AMEN1HRH4KIF18ANOS3 | |
| SCHEMBL30788620 | 0.80 | HRH4 (0.58) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL22148449 | 0.80 | HRH4 (0.58) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL31120933 | 0.79 | NOS3 (0.38) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL30788632 | 0.79 | NOS3 (0.41) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL29187344 | 0.79 | NOS3 (0.41) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL31470240 | 0.79 | KMT2A (0.35) | KMT2AMEN1HRH4KDM4EHPGD | |
| SCHEMBL24818277 | 0.78 | KDM4E (0.36) | KMT2AMEN1HRH4KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146973-A1 | SYNTHESIS OF A KIF18A INHIBITOR | AMGEN INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2020132649-A1 | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |