Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216324 | 0.91 | PLAU (0.43) | PIK3CAMTORROCK2ESR2MAPT | |
| SCHEMBL2882070 | 0.90 | PLG (0.43) | PIK3CAMTORABL1PDGFRBKIT | |
| SCHEMBL2209752 | 0.89 | ABCB1 (0.41) | PIK3CAMTORROCK2ESR2NAMPT | |
| SCHEMBL2214996 | 0.89 | ESR2 (0.41) | PIK3CAMTORABL1PDGFRBKIT | |
| SCHEMBL2214210 | 0.83 | WNT1 (0.42) | ROCK2RAD52JAK2MAP3K5POLB | |
| SCHEMBL2216413 | 0.82 | CYP17A1 (0.49) | MAPTABCB1RAD52BRAFJAK2 | |
| SCHEMBL2213296 | 0.81 | JAK2 (0.39) | PIK3CAMTORABL1PDGFRBKIT | |
| SCHEMBL2213189 | 0.80 | PTGIR (0.41) | NAMPTSCN9AJAK2CYP17A1POLB | |
| SCHEMBL2215002 | 0.78 | JAK2 (0.45) | KITPDGFRAMAPTRAD52JAK2 | |
| SCHEMBL2211305 | 0.77 | NAMPT (0.47) | NAMPTMAPTSCN3ASCN4ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |