Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | MELK | Q14680 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214775 | 0.89 | PLAU (0.49) | WNT1GSK3BDYRK1AF2PLG | |
| SCHEMBL2213856 | 0.87 | MELK (0.48) | WNT1GSK3BDYRK1AF2PLG | |
| SCHEMBL2215892 | 0.87 | PLG (0.45) | WNT1GSK3BDYRK1AF2PLG | |
| SCHEMBL2211714 | 0.86 | MELK (0.46) | WNT1GSK3BDYRK1AF2PLG | |
| SCHEMBL2214893 | 0.83 | PIK3CA (0.40) | JAK2POLBMCL1TDP1ROCK2 | |
| SCHEMBL2215002 | 0.82 | JAK2 (0.45) | JAK2POLBMCL1TDP1MEN1 | |
| SCHEMBL2881428 | 0.81 | FYN (0.51) | GSK3BPOLBMEN1KMT2ARAD52 | |
| SCHEMBL2214475 | 0.80 | JAK2 (0.43) | JAK2POLBMCL1TDP1MEN1 | |
| SCHEMBL2215111 | 0.79 | F2 (0.40) | WNT1GSK3BDYRK1AF2PLG | |
| SCHEMBL2880155 | 0.79 | PLK1 (0.43) | JAK2MEN1KMT2ARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |