SCHEMBL22149282

SCHEMBL22149282

COc1cc(C(N)CCC(F)(F)F)oc(=O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
APEX1 P27695 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 9/20 0.39
HPGD P15428 8/20 0.39
HSD17B10 Q99714 6/20 0.39
TP53 P04637 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
CYP3A4 P08684 2/20 0.38
DYRK1A Q13627 1/20 0.37
AR P10275 1/20 0.36
KIF11 P52732 2/20 0.35
AAK1 Q2M2I8 1/20 0.34
KDM4E B2RXH2 6/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22149726 1.00 MAPT (0.41) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149518 0.83 MAPT (0.44) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149509 0.83 MAPT (0.44) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149256 0.83 MAPT (0.44) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149724 0.77 L3MBTL1 (0.44) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149727 0.77 CYP3A4 (0.38) MAPTTDP1MEN1POLBAPEX1
SCHEMBL22149254 0.77 L3MBTL1 (0.44) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL26046527 0.70 ALDH1A1 (0.46) MAPTL3MBTL1TDP1MEN1POLB
SCHEMBL22149725 0.70 KDM4E (0.42) MAPTTDP1POLBALDH1A1HPGD
SCHEMBL22149505 0.70 KDM4E (0.42) MAPTTDP1POLBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3898613-B1 ANTICANCER COMPOUNDS PHARMA MAR SA (ES) 2023-08-09 EP disclosed
US-20220056021-A1 ANTICANCER COMPOUNDS PHARMA MAR, S.A. (ES) 2022-02-24 US disclosed
WO-2020127194-A1 ANTICANCER COMPOUNDS PHARMA MAR, S.A. (ES) 2020-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220056021-A1 ANTICANCER COMPOUNDS TP53, MCL1, MYC MAPT 3137/4885L3MBTL1 1432/4885TDP1 2015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.