SCHEMBL2215259

SCHEMBL2215259

CCCCCn1cc(N)c(=O)[nH]c1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.60
CYP2C19 P33261 3/20 0.60
KMT2A Q03164 3/20 0.60
GAA P10253 3/20 0.60
CYP2C9 P11712 2/20 0.60
MEN1 O00255 2/20 0.60
TDP1 Q9NUW8 1/20 0.60
MAPT P10636 2/20 0.50
TK1 P04183 2/20 0.43
ATM Q13315 1/20 0.43
ALDH1A1 P00352 2/20 0.41
PDE4A P27815 2/20 0.40
ADORA2A P29274 2/20 0.40
PDE4B Q07343 2/20 0.40
PDE4C Q08493 2/20 0.40
PDE4D Q08499 2/20 0.40
KDM4E B2RXH2 3/20 0.40
TLR8 Q9NR97 1/20 0.40
HTT P42858 1/20 0.40
TK2 O00142 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20359507 0.88 CYP1A2 (0.45) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL13261412 0.81 TK1 (0.62) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL10976239 0.80 CYP1A2 (0.60) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL6890252 0.80 TK1 (0.65) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL7181578 0.80 CYP1A2 (0.60) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL6883307 0.80 TK1 (0.65) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL18226895 0.80 TK1 (0.65) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL10337895 0.80 TK1 (0.65) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL13314161 0.80 CYP1A2 (0.56) CYP1A2CYP2C19KMT2AGAACYP2C9
SCHEMBL6760088 0.79 CYP1A2 (0.62) CYP1A2CYP2C19KMT2AGAACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342616-A2 CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION Alnylam Pharmaceuticals Inc. (US) 2011-07-13 EP disclosed
WO-2010039548-A2 CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION ALNYLAM PHARMACEUTICALS, INC. (US) 2010-04-08 WO disclosed