Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17371770 | 0.93 | HASPIN (0.43) | HASPINDYRK2TYMPTDP1RXRA | |
| SCHEMBL2930015 | 0.85 | HASPIN (0.35) | HASPINDYRK2TYMPTDP1RXRA | |
| SCHEMBL7181586 | 0.83 | TYMP (0.39) | HASPINDYRK2TYMPTDP1 | |
| SCHEMBL10981137 | 0.83 | TYMP (0.39) | HASPINDYRK2TYMPTDP1 | |
| SCHEMBL16990470 | 0.83 | ADORA2A (0.46) | TYMPTDP1 | |
| SCHEMBL4348692 | 0.81 | ADRA1D (0.37) | TYMP | |
| SCHEMBL7099892 | 0.81 | ADORA2A (0.47) | TDP1 | |
| SCHEMBL24205164 | 0.80 | TYMP (0.35) | HASPINTYMP | |
| SCHEMBL10598541 | 0.79 | FABP4 (0.50) | TYMP | |
| SCHEMBL26034489 | 0.79 | TYMP (0.36) | HASPINDYRK2TYMPTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342616-A2 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION | Alnylam Pharmaceuticals Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010039548-A2 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |