Rebamipide

Rebamipide

SCHEMBL221527

O=C(NC(Cc1cc(=O)[nH]c2ccccc12)C(=O)O)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
UBASH3B Q8TF42 1/20 1.00
PPARG P37231 1/20 0.55
ITGB2 P05107 6/20 0.55
ICAM1 P05362 6/20 0.55
ITGAL P20701 6/20 0.55
F11 P03951 2/20 0.54
ERAP2 Q6P179 1/20 0.54
TACR1 P25103 2/20 0.52
CCKBR P32239 1/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
CA2 P00918 1/20 0.48
PIN1 Q13526 1/20 0.48
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA9 Q16790 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rebamipide SCHEMBL21623658 1.00 UBASH3B (1.00) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL29560992 1.00 UBASH3B (1.00) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL23346201 1.00 UBASH3B (1.00) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL5794018 1.00 UBASH3B (1.00) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL9114879 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL28798513 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL27819911 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL2292009 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL26607917 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL
Rebamipide SCHEMBL27858766 0.99 UBASH3B (0.98) UBASH3BPPARGITGB2ICAM1ITGAL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4619 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075220-A Contact lens for treating xerophthalmia and preparation method thereof 2026-05-26 CN claimed
CN-121574094-B Rebamipide Fu Nuola raw salt and preparation method and application thereof 湖南先施制药有限公司 2026-05-19 CN claimed
CN-122031407-A Rebamipide tablet and preparation method thereof 泰州市第四人民医院 2026-05-15 CN claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260102359-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION ERESINA LLC (US) 2026-04-16 US claimed
US-20260078448-A1 METHODS OF DETECTING SJÖGREN'S SYNDROME USING SALIVARY EXOSOMES EXOSOME DIAGNOSTICS INC (US) 2026-03-19 US claimed
CN-121574094-A Rebamipide Fu Nuola raw salt and preparation method and application thereof 湖南先施制药有限公司 2026-02-27 CN claimed
US-12478627-B2 Irsogladine for the treatment of eosinophilic gastrointestinal diseases EPITHELION SCIENCE BIOTECH, S.L. (ES) 2025-11-25 US claimed
EP-4593859-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION Eresina, LLC (US) 2025-08-06 EP claimed
US-12370140-B2 Micelle for solubilizing a sparingly water-soluble ingredient and solution comprising the same TEIKA PHARMACEUTICAL CO., LTD. (JP) 2025-07-29 US claimed
US-5480891-A CARBOSTYRIL DERIVATIVES, NON-INSULIN DEPENDENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-01-02 US claimed
US-5476858-A Treats esophagitis, alzheimer's disease, hepatitis, and acromegalia OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-12-19 US claimed
EP-0674515-A1 CARBOSTYRIL DERIVATIVE FOR INHIBITING PRODUCTION OF INTERLEUKIN-8 OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-10-04 EP claimed
WO-1995012579-A1 BISMUTH SALT OF CARBOSTYRIL DERIVATIVES FOR THE TREATMENT OF PEPTIC ULCERS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1995-05-11 WO claimed
WO-1995011026-A1 CARBOSTYRIL DERIVATIVE FOR INHIBITING PRODUCTION OF INTERLEUKIN-8 OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-04-27 WO claimed
EP-0621782-A1 AGENT FOR PREVENTING AND TREATING DISTURBANCES OF INTESTINAL MUCOUS MEMBRANE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP claimed
WO-1994012182-A1 AGENT FOR PREVENTING AND TREATING DISTURBANCES OF INTESTINAL MUCOUS MEMBRANE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-09 WO claimed
EP-0594867-A1 AGENT FOR INCREASING SOMATOSTATIN OR FOR INHIBITING DECREASE OF SOMATOSTATIN OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-05-04 EP claimed
WO-1993023043-A1 AGENT FOR INCREASING SOMATOSTATIN OR FOR INHIBITING DECREASE OF SOMATOSTATIN OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1993-11-25 WO claimed
EP-0543018-A1 Antidiabetic agent OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-05-26 EP claimed