Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.57 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665058 | 1.00 | CFTR (0.70) | CFTRMEN1KMT2ANLRP3APEX1 | |
| SCHEMBL2215803 | 1.00 | CFTR (0.70) | CFTRMEN1KMT2ANLRP3APEX1 | |
| SCHEMBL5119828 | 1.00 | CFTR (0.70) | CFTRMEN1KMT2ANLRP3APEX1 | |
| SCHEMBL7202246 | 0.90 | CFTR (0.64) | CFTRMEN1KMT2ANLRP3APEX1 | |
| SCHEMBL6789054 | 0.90 | CFTR (0.64) | CFTRMEN1KMT2ANLRP3APEX1 | |
| SCHEMBL3892654 | 0.89 | APEX1 (0.71) | MEN1KMT2AAPEX1LCKMAP3K5 | |
| SCHEMBL3892650 | 0.89 | APEX1 (0.71) | MEN1KMT2AAPEX1LCKMAP3K5 | |
| SCHEMBL3896597 | 0.89 | LCK (0.68) | CFTRMEN1KMT2AAPEX1LCK | |
| SCHEMBL29554158 | 0.89 | LCK (0.68) | CFTRMEN1KMT2AAPEX1LCK | |
| SCHEMBL3896603 | 0.89 | LCK (0.68) | CFTRMEN1KMT2AAPEX1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178142-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2011-07-21 | — | — | US | claimed |
| WO-2010044103-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2010-04-22 | — | — | WO | claimed |
| EP-2539305-B1 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | US HEALTH (US) | 2017-02-15 | — | — | EP | disclosed |
| US-9169182-B2 | Chrysophaentin analogs that inhibit FtsZ protein | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-10-27 | — | — | US | disclosed |
| EP-2678297-A2 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20130331460-A1 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2013-12-12 | — | — | US | disclosed |
| US-8399689-B2 | Chrysophaentin antimicrobial compounds that inhibit FtsZ protein | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-03-19 | — | — | US | disclosed |
| EP-2539305-A2 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2013-01-02 | — | — | EP | disclosed |
| US-20120316227-A1 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2012-12-13 | — | — | US | disclosed |
| WO-2012116254-A2 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-08-30 | — | — | WO | disclosed |
| WO-2011106630-A2 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-09-01 | — | — | WO | disclosed |
| US-20110178142-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2011-07-21 | — | — | US | disclosed |
| US-20110178142-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2011-07-21 | — | — | US | disclosed |
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2010-07-29 | — | — | US | disclosed |
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2010-07-29 | — | — | US | disclosed |
| WO-2010044103-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010044103-A1 | PHARMACEUTICAL COMPOSITION FOR THERAPEUTIC OR PROPHYLACTIC TREATMENT OF BACTERIAL INFECTIONS AND ASSOCIATED DISEASES | NATIONAL INSTITUTE OF IMMUNOLOGY (IN) | 2010-04-22 | — | — | WO | disclosed |
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2008-02-28 | — | — | US | disclosed |
| EP-1834642-A2 | 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | National Institute of Immunology (IN) | 2007-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190832-A1 | Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates | TTR, TPR, POT1 | CFTR 4494/4885MEN1 3323/4885KMT2A 4011/4885 |
| US-20120316227-A1 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | CEP170, CDC42, CIAPIN1 | CFTR 1800/4885MEN1 3242/4885KMT2A 3500/4885 |
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | FASN, FADS2, TECR | CFTR 4038/4885MEN1 4839/4885KMT2A 2463/4885 |
| US-20130331460-A1 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | CDC42, CEP170, FNTA | CFTR 1789/4885MEN1 2585/4885KMT2A 2219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.