Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | FURIN | P09958 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22158954 | 1.00 | SCN4A (0.43) | SCN4ASCN9ANFE2L2CRHBPCRHR2 | |
| SCHEMBL22158956 | 1.00 | SCN4A (0.43) | SCN4ASCN9ANFE2L2CRHBPCRHR2 | |
| SCHEMBL30360130 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL1888233 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL1229972 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL25197894 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL25197895 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL22713540 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL1888234 | 0.91 | TRPA1 (0.40) | NFE2L2ALDH1A1LMNATRPA1NPC1 | |
| SCHEMBL22159234 | 0.86 | NPC1 (0.47) | SOS1FURINALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020141439-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-09 | — | — | WO | disclosed |
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | IDH1, IDH2, IDH3A | SCN4A 2817/4885SCN9A 1530/4885NFE2L2 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.