Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140132 | 0.72 | KDM4E (0.40) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL5134333 | 0.72 | CA12 (0.34) | CA12CA1CA9CYP3A4MAPT | |
| SCHEMBL3799324 | 0.70 | CA12 (0.57) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL3164161 | 0.69 | CA12 (0.48) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL2192615 | 0.69 | KDM4E (0.48) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL4499932 | 0.69 | KDM4E (0.50) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL6448403 | 0.69 | NPC1 (0.45) | CA12CA1CA9CYP3A4ALDH1A1 | |
| SCHEMBL7143392 | 0.68 | VKORC1 (0.71) | CYP3A4ALDH1A1KDM4EVKORC1NQO1 | |
| SCHEMBL3988877 | 0.68 | GAA (0.57) | CYP3A4ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5478821 | 0.68 | VKORC1 (0.51) | CA12CA1CA9CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994323-B2 | Chromen-2-one derivatives | NEUROSEARCH A/S (DK) | 2011-08-09 | — | — | US | disclosed |
| EP-2158200-B1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NEUROSEARCH AS (DK) | 2011-07-13 | — | — | EP | disclosed |
| US-20100217002-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-08-26 | — | — | US | disclosed |
| EP-2158200-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NeuroSearch A/S (DK) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008138854-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | NEUROSEARCH A/S (DK) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217002-A1 | NOVEL CHROMEN-2-ONE DERIVATIVES | CBX2, CYP2J2, CDYL2 | CA12 1775/4885CA1 4334/4885CA9 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.