Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18740713 | 0.76 | — | — | |
| SCHEMBL7321483 | 0.76 | CHRM5 (0.60) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| Hydrochloric Acid SCHEMBL7331633 | 0.74 | CHRM5 (0.57) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL23692548 | 0.72 | LMNA (0.33) | — | |
| SCHEMBL23885975 | 0.72 | — | — | |
| SCHEMBL15823304 | 0.71 | CHRM5 (0.45) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL17284218 | 0.70 | CHRM5 (0.48) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| Hydrochloric Acid SCHEMBL12501508 | 0.69 | HRH3 (0.35) | CHRM5ADRA2C | |
| SCHEMBL18202943 | 0.67 | — | — | |
| SCHEMBL23775583 | 0.67 | ALOX15 (0.62) | CHRM5ADRA2CACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150361-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | BEIGENE, LTD. (KY) | 2024-05-09 | — | — | US | disclosed |
| US-11905294-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kδ inhibitors | BEIGENE, LTD. (KY) | 2024-02-20 | — | — | US | disclosed |
| EP-4219502-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | BeiGene, Ltd. (KY) | 2023-08-02 | — | — | EP | disclosed |
| EP-3679042-B1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | BEIGENE LTD (KY) | 2023-03-01 | — | — | EP | disclosed |
| CN-111704615-B | Imidazo [1,5-A ] pyrazine derivatives as PI3Kdelta inhibitors | 百济神州有限公司 | 2023-02-17 | — | — | CN | disclosed |
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | BEIGENE, LTD. (KY) | 2022-01-11 | — | — | US | disclosed |
| CN-111704615-A | Imidazo [1,5-A ] pyrazine derivatives as PI3K inhibitors | 百济神州有限公司 | 2020-09-25 | — | — | CN | disclosed |
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2020-07-02 | — | — | US | disclosed |
| CN-111051312-A | Imidazo [1,5-A ] pyrazine derivatives as PI3K delta inhibitors | 百济神州有限公司 | 2020-04-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | PIK3CD, PIK3R5, PIK3CA | CHRM5 4753/4885ADRA2C 871/4885SCN1A 270/4885 |
| US-11905294-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kδ inhibitors | PIK3CD, PIK3R5, PIK3CA | CHRM5 4803/4885ADRA2C 1315/4885SCN1A 246/4885 |
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | PIK3CD, PIK3R5, PIK3CA | CHRM5 4753/4885ADRA2C 871/4885SCN1A 270/4885 |
| US-20240150361-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | PIK3CD, PIK3R5, PIK3CA | CHRM5 4753/4885ADRA2C 871/4885SCN1A 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.