Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 7/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122927 | 0.88 | TTK (0.45) | PTK6MAPKAPK5TTK | |
| SCHEMBL22123879 | 0.86 | PTK6 (0.48) | PTK6TTKLCKAURKB | |
| SCHEMBL22154151 | 0.86 | PTK6 (0.42) | PTK6TTKLCKAURKBADORA3 | |
| SCHEMBL30172049 | 0.86 | PTK6 (0.42) | PTK6TTKLCKAURKBADORA3 | |
| SCHEMBL22123835 | 0.85 | PTK6 (0.42) | PTK6TTKLCKAURKB | |
| SCHEMBL30171819 | 0.84 | PTK6 (0.46) | PTK6TTKLCKAURKB | |
| SCHEMBL22139109 | 0.84 | PTK6 (0.46) | PTK6TTKLCKAURKB | |
| SCHEMBL24112398 | 0.84 | PTK6 (0.44) | PTK6TTKLCKAURKBAXL | |
| SCHEMBL22139113 | 0.82 | PTK6 (0.48) | PTK6MAPKAPK5LCKAURKBCSF1R | |
| SCHEMBL30172107 | 0.82 | PTK6 (0.48) | PTK6MAPKAPK5LCKAURKBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |