Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214347 | 0.89 | MAPK14 (0.52) | ROCK2ROCK1MAPK14MAPK11RIPK2 | |
| SCHEMBL2217376 | 0.89 | MAPK14 (0.45) | DRD4ROCK2ROCK1MAPK14MAPK11 | |
| SCHEMBL2214420 | 0.88 | MAPK14 (0.56) | DRD4ROCK2ROCK1MAPK14MAPK11 | |
| SCHEMBL1416977 | 0.88 | MAPK14 (0.56) | CCR1DRD4MAPK14MAPK11DDR2 | |
| SCHEMBL2215688 | 0.86 | MAPK14 (0.48) | MAPK14MAPK11 | |
| SCHEMBL2214745 | 0.85 | MAPK14 (0.44) | ROCK2ROCK1MAPK14MAPK11 | |
| SCHEMBL2216554 | 0.84 | MAPK14 (0.47) | DRD4MAPK14MAPK11 | |
| SCHEMBL2215757 | 0.82 | MAPK14 (0.46) | MAPK14MAPK11 | |
| SCHEMBL2213705 | 0.82 | MAPK14 (0.52) | MAPK14MAPK11RIPK2 | |
| SCHEMBL2218498 | 0.82 | MAPK14 (0.46) | DRD4MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |