Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031488 | 0.79 | ALDH1A1 (0.54) | TSHRMAPK1ESR1PKMSMN1; SMN2 | |
| Alcohol SCHEMBL28160506 | 0.74 | SMN1; SMN2 (0.50) | TSHRMAPK1ESR1SMN1; SMN2RECQL | |
| SCHEMBL9853251 | 0.74 | ALDH1A1 (0.47) | TSHRMAPK1ESR1ALDH1A1 | |
| Alcohol SCHEMBL2831424 | 0.72 | ALDH1A1 (0.53) | TSHRESR1SMN1; SMN2RECQLTDP1 | |
| SCHEMBL6888914 | 0.72 | TSHR (0.45) | TSHRMAPK1ESR1RECQLTDP1 | |
| SCHEMBL5560398 | 0.71 | KMT2A (0.50) | MAPK1ESR1SMN1; SMN2RECQLHTT | |
| Alcohol SCHEMBL27672609 | 0.70 | ALDH1A1 (0.50) | TSHRESR1SMN1; SMN2RECQLTDP1 | |
| SCHEMBL522227 | 0.70 | ESR1 (0.55) | TSHRMAPK1ESR1SMN1; SMN2RECQL | |
| SCHEMBL10586717 | 0.70 | ALDH1A1 (0.47) | MAPK1ESR1PKMSMN1; SMN2RECQL | |
| Alcohol SCHEMBL29191762 | 0.69 | SMN1; SMN2 (0.43) | TSHRMAPK1ESR1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745334-B2 | Method for synthesizing 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol | ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD (CN) | 2020-08-18 | — | — | US | disclosed |
| US-20200207693-A1 | METHOD FOR SYNTHESIZING 2,3,5,6-TETRAFLUORO-4-METHOXYMETHYL BENZYL ALCOHOL | ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD (CN) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745334-B2 | Method for synthesizing 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol | TET2, TH, ALKBH2 | TSHR 1978/4885MAPK1 1853/4885ESR1 3267/4885 |
| US-20200207693-A1 | METHOD FOR SYNTHESIZING 2,3,5,6-TETRAFLUORO-4-METHOXYMETHYL BENZYL ALCOHOL | TH, ALKBH2, ALKBH3 | TSHR 1585/4885MAPK1 2141/4885ESR1 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.