SCHEMBL221618

SCHEMBL221618

Nc1cccc2c1C(=O)NC2=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 0.53
CASP7 P55210 2/20 0.53
MEN1 O00255 1/20 0.53
RGS12 O14924 1/20 0.53
USP2 O75604 1/20 0.53
CYP1A2 P05177 1/20 0.53
POLB P06746 1/20 0.53
CYP3A4 P08684 1/20 0.53
MAPT P10636 1/20 0.53
THRB P10828 1/20 0.53
CYP2C9 P11712 1/20 0.53
APEX1 P27695 1/20 0.53
CASP1 P29466 1/20 0.53
BRCA1 P38398 1/20 0.53
MTOR P42345 1/20 0.53
RECQL P46063 1/20 0.53
BLM P54132 1/20 0.53
GNAI1 P63096 1/20 0.53
HBB P68871 1/20 0.53
PMP22 Q01453 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372946 1.00 PARP1 (0.53) PARP1CASP7MEN1RGS12USP2
SCHEMBL28012033 0.98 PARP1 (0.52) PARP1CASP7MEN1RGS12USP2
Alcohol SCHEMBL11504765 0.89 KDM4E (0.47) PARP1CASP7MEN1RGS12USP2
SCHEMBL27277884 0.88 ADORA2A (0.57) PARP1CASP7MEN1RGS12USP2
Pyridine SCHEMBL27532836 0.88 PARP1 (0.44) PARP1CASP7MEN1RGS12USP2
SCHEMBL18660318 0.86 PARP1 (0.45) PARP1CASP7MEN1RGS12USP2
SCHEMBL7806626 0.86 GSK3B (0.52) PARP1CASP7MEN1RGS12USP2
SCHEMBL7599788 0.85 PARP1 (0.58) PARP1CASP7MEN1RGS12USP2
SCHEMBL29260788 0.82 PARP1 (0.40) PARP1CASP7MEN1RGS12USP2
SCHEMBL3988383 0.82 ADORA2A (0.46) PARP1CASP7MEN1RGS12USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118186618-B Medical antibacterial bedding fabric and preparation process thereof 海南洁达投资有限公司 2024-12-24 CN claimed
CN-119076058-A Carbon intercalation iron phthalocyanine heterogeneous junction and preparation method and application thereof 南京大学 2024-12-06 CN claimed
CN-118320644-A Organic solvent-resistant separation membrane and preparation method thereof 苏州纳信膜技术有限公司 2024-07-12 CN claimed
CN-118186618-A Medical antibacterial bedding fabric and preparation process thereof 海南洁达投资有限公司 2024-06-14 CN claimed
CN-117645638-A Fullerene derivative, and preparation method and application thereof 中国科学院化学研究所 2024-03-05 CN claimed
CN-115626916-B Pomalidomide derivative as well as preparation method and application thereof 河南科技大学第一附属医院 2024-01-30 CN claimed
US-20230364243-A1 CANCER-SELECTIVE TARGET DEGRADATION BY TARGETING GROUP CAGED PROTACS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2023-11-16 US claimed
CN-115636815-B Preparation method and application of pomalidomide connected urea compound 新乡学院 2023-10-27 CN claimed
CN-113929748-B Kit for detecting BACE1 enzyme activity and application thereof 中国科学技术大学 2023-10-20 CN claimed
US-11725227-B2 Devices and methods for examining drug effects on microorganisms ESSENLIX CORPORATION (US) 2023-08-15 US claimed
WO-1998023690-A9 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS 1998-09-17 WO claimed
WO-1998023690-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1998-06-04 WO claimed
CN-1136275-A Arylheterocyclylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics HOECHST ROUSSEL PHARMA (US) 1996-11-20 CN claimed
EP-0445926-B1 Organic materials having sulfonamido linked poly(oxyalkylene) moieties and their preparation MILLIKEN RES CORP (US) 1996-08-21 EP claimed
US-5529869-A IMPROVED ELECTRICAL CHARGE ACCEPTANCE AND CHARGE RETENTION ABILITY HEWLETT-PACKARD COMPANY (US) 1996-06-25 US claimed
EP-0605566-A1 LIGHT-ABSORBING POLYURETHANE COMPOSITIONS AND THERMOPLASTIC POLYMERS COLORED THEREWITH EASTMAN CHEMICAL COMPANY (US) 1994-07-13 EP claimed
WO-1993006147-A1 LIGHT-ABSORBING POLYURETHANE COMPOSITIONS AND THERMOPLASTIC POLYMERS COLORED THEREWITH EASTMAN KODAK COMPANY (US) 1993-04-01 WO claimed
US-4992204-A LUMINOPHORE LINKED TO POLYALKYLENE MOIETY MILIKEN RESEARCH CORPORATION (US) 1991-02-12 US claimed
US-4682983-A Transfer sheet for the thermal dry impression of cellulose fibers SICPA HOLDING S.A. (CH) 1987-07-28 US claimed
EP-0099333-B1 TRANSFER SHEETS FOR THE THERMAL DRY-PRINTING OF CELLULOSIC FIBRES SICPA HOLDING S.A. (CH) 1986-09-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230364243-A1 CANCER-SELECTIVE TARGET DEGRADATION BY TARGETING GROUP CAGED PROTACS ADRM1, MYC, SKP2 PARP1 1231/4885CASP7 2149/4885MEN1 3761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.