SCHEMBL221650

SCHEMBL221650

COc1ccc(C(c2ccccc2)(c2ccccc2)C(N)[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2OP(N)O)cc1

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.44
TK1 P04183 3/20 0.42
NT5M Q9NPB1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8598213 0.93 RNASE1 (0.45) RNASE1TK1NT5M
SCHEMBL152181 0.84 RNASE1 (0.48) RNASE1
SCHEMBL10572312 0.83 TK1 (0.47) TK1
SCHEMBL6514654 0.82 RNASE1 (0.48) RNASE1TK1
SCHEMBL6536529 0.82 RNASE1 (0.48) RNASE1TK1
SCHEMBL17825659 0.82 RNASE1 (0.35) RNASE1TK1
SCHEMBL10802980 0.81 RNASE1 (0.43) RNASE1TK1NT5M
SCHEMBL8426287 0.81 TK1 (0.45) RNASE1TK1NT5M
SCHEMBL14815673 0.81 RNASE1 (0.43) RNASE1TK1NT5M
SCHEMBL7535867 0.80 TK1 (0.52) TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1842918-B2 Receptor nucleic acids and polypeptides BIOGEN MA INC (US) 2016-07-27 EP disclosed
EP-2325317-B2 Receptor nucleic acids and polypeptides BIOGEN MA INC (US) 2016-07-27 EP disclosed
EP-2184359-B1 Flax (Linum usitatissimum L.) seed-specific promoters BIORIGINAL FOOD & SCIENCE CORP (CA) 2016-03-02 EP disclosed
US-8841512-B2 Flax (Linum usitatissimum L.) seed-specific promotors BIORIGINAL FOOD & SCIENCE CORPORATION (CA) 2014-09-23 US disclosed
US-8524672-B2 Method for inhibiting BAFF-R activity BIOGEN IDEC MA INC. (US) 2013-09-03 US disclosed
EP-2325317-B1 Receptor nucleic acids and polypeptides BIOGEN IDEC INC (US) 2012-11-07 EP disclosed
EP-1842918-B1 Receptor nucleic acids and polypeptides BIOGEN IDEC INC (US) 2012-04-18 EP disclosed
US-20120070437-A1 METHOD OF IDENTIFYING COMPOUNDS THAT BIND BAFF-R BIOGEN IDEC MA INC. 2012-03-22 US disclosed
US-8088978-B2 Omega-3 fatty acid desaturase family members and uses thereof BIORIGINAL FOOD & SCIENCE CORP. (CA) 2012-01-03 US disclosed
US-8030470-B2 Isolated nucleic acids encoding farnesyltransferase polypeptides PERFORMANCE PLANTS, INC. (CA) 2011-10-04 US disclosed
WO-1999052945-A9 NOVEL MOLECULES OF THE BGCKr-RELATED PROTEIN FAMILY AND USES THEREOF MILLENIUM PHARMACEUTICALS INC (US) 2000-02-03 WO disclosed
WO-1999062943-A2 NOVEL MOLECULES OF THE AIP-RELATED PROTEIN FAMILY AND USES THEREOF MILLENIUM PHARMACEUTICALS, INC. (US) 1999-12-09 WO disclosed
WO-1999054437-A2 NOVEL MOLECULES OF THE T125-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 1999-10-28 WO disclosed
WO-1999054343-A2 NOVEL MOLECULES OF THE T139-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 1999-10-28 WO disclosed
WO-1999052945-A2 NOVEL MOLECULES OF THE BGCKr-RELATED PROTEIN FAMILY AND USES THEREOF MILLENIUM PHARMACEUTICALS, INC. (US) 1999-10-21 WO disclosed
WO-1999052924-A1 NOVEL MOLECULES OF THE T129-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 1999-10-21 WO disclosed
WO-1999040102-A1 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 1999-08-12 WO disclosed
WO-1999011662-A1 NOVEL MOLECULES OF THE TNFR-LIGAND-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM BIOTHERAPEUTICS, INC. (US) 1999-03-11 WO disclosed
WO-1999006426-A1 NOVEL MOLECULES OF THE TANGO-77 RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM BIOTHERAPEUTICS, INC. (US) 1999-02-11 WO disclosed
WO-1998048051-A2 NOVEL MOLECULES OF THE FTHMA-070-RELATED PROTEIN FAMILY AND THE T85-RELATED PROTEIN FAMILY AND USES THEREOF MILLENNIUM BIOTHERAPEUTICS, INC. (US) 1998-10-29 WO disclosed