Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22178978 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ATUBB4ATUBB | |
| SCHEMBL29542273 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ATUBB4ATUBB | |
| SCHEMBL11266182 | 0.73 | MEN1 (0.47) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL22165488 | 0.73 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AMAPTTP53 | |
| SCHEMBL167812 | 0.71 | MAPT (0.56) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL12322230 | 0.69 | ALDH1A1 (0.55) | LIPESMN1; SMN2KMT2ATUBB4ATUBB | |
| SCHEMBL29172704 | 0.68 | MEN1 (0.42) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL5211841 | 0.68 | MEN1 (0.47) | MEN1KMT2AMAPTPOLBTP53 | |
| SCHEMBL22179002 | 0.67 | MEN1 (0.41) | SMN1; SMN2MEN1KMT2AMAPTTP53 | |
| SCHEMBL4295525 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2MEN1KMT2ATUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3902804-A1 | AZA-HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | Les Laboratoires Servier SAS (FR) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020139992-A1 | AZA-HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2020-07-02 | — | — | WO | disclosed |