Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194802 | 0.81 | MAPT (0.43) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL6043168 | 0.78 | KMT2A (0.47) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL12062616 | 0.78 | MEN1 (0.46) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11266182 | 0.78 | MEN1 (0.47) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL170064 | 0.77 | KDM4E (0.44) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL25911400 | 0.77 | KDM4E (0.44) | MEN1KMT2ACYP2C19ALDH1A1KDM4E | |
| SCHEMBL28135917 | 0.77 | KDM4E (0.44) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL29556850 | 0.75 | ALDH1A1 (0.55) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL145005 | 0.75 | ALDH1A1 (0.55) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL2714124 | 0.75 | KMT2A (0.56) | MAPTL3MBTL1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362335-B1 | — | — | None | — | — | US | disclosed |
| CN-216946816-U | 2-amino-5, 8-dimethoxy [1,2,4] triazolo [1,5-C ] pyrimidine production system | 内蒙古蓝科生物科技有限公司 | 2022-07-12 | — | — | CN | disclosed |
| EP-2473486-B1 | PYRIMIDINES AS HEPCIDINE ANTAGONISTS | VIFOR INT AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| EP-1615898-B1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
| EP-1979331-B1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-8076364-B2 | Trisubstituted amine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-12-13 | — | — | US | disclosed |
| US-8076364-B2 | Trisubstituted amine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-12-13 | — | — | US | disclosed |
| EP-1453516-A2 | NOVEL TRI-SUBSTITUTED PYRIMIDINES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2004050640-A1 | PYRIMIDINE-SULFAMIDES AND THEIR USE AS ENDOTHELIAN RECEPTOR ANTAGONIST | ACTELION PHARMACEUTICALS LTD (CH) | 2004-06-17 | — | — | WO | disclosed |
| EP-1289994-B1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY 1,2,4]TRIAZOLO 1,5-c]PYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2004-03-17 | — | — | EP | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
| WO-2003032994-A2 | NOVEL TRI-SUBSTITUTED PYRIMIDINES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-1289994-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY 1,2,4]TRIAZOLO 1,5-c]PYRIMIDINE | Dow AgroSciences LLC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6362335-B2 | CONTACTING 3-AMINO-8-METHOXY(1,2,4) TRIAZOLO(4,3-C)PYRIMIDINE COMPOUNDS WITH SODIUM OR POTASSIUM METHOXIDE IN AN ALCOHOL SOLVENT | DOW AGROSCIENCES LLC | 2002-03-26 | — | — | US | disclosed |
| US-20020013230-A1 | Process for the preparation of 2-amino-5, 8-dimethoxy (1,2,4) triazolo (1,5-c) pyrimidine | CORTEVA AGRISCIENCE LLC | 2002-01-31 | — | — | US | disclosed |
| WO-2001098305-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2001-12-27 | — | — | WO | disclosed |
| EP-0343752-A1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DowElanco (US) | 1989-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013230-A1 | Process for the preparation of 2-amino-5, 8-dimethoxy (1,2,4) triazolo (1,5-c) pyrimidine | PYM1, THPO, ADH1C | MAPT 2412/4885L3MBTL1 2473/4885MEN1 1632/4885 |
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | MAPT 13/4885L3MBTL1 3293/4885MEN1 3119/4885 |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | HAMP, DHPS, SLC40A1 | MAPT 4432/4885L3MBTL1 3829/4885MEN1 4413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.