Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CDC7 | O00311 | 2/20 | 0.56 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734395 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL735258 | 0.79 | ALDH1A1 (0.67) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL735179 | 0.79 | HSD17B10 (0.64) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL733471 | 0.77 | HSD17B10 (0.61) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL20409291 | 0.77 | ALDH1A1 (0.61) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL734722 | 0.75 | ALDH1A1 (0.59) | ALDH1A1HSD17B10RXFP1KDM4EGAA | |
| SCHEMBL24846338 | 0.75 | ALDH1A1 (0.75) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL18415242 | 0.74 | SMN1; SMN2 (0.77) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL12264959 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HSD17B10RXFP1KDM4EHPGD | |
| SCHEMBL735038 | 0.73 | PIK3CG (0.75) | ALDH1A1HSD17B10RXFP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695349-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695349-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PIK3CG | ALDH1A1 4628/4885HSD17B10 2243/4885RXFP1 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.