SCHEMBL22167172

SCHEMBL22167172

CCCC1CCC(C2CC=C(c3cnc(-c4ccc(CC(NC(=O)c5ccc(C(C)(C)C)s5)C(=O)N5CC[C@H](C(=O)O)C5)cc4)nc3)CC2)CC1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ F2 P00734 13/20 0.33
▸ PRCP P42785 1/20 0.31
▸ PLG P00747 1/20 0.31
▸ PLAU P00749 1/20 0.31
▸ F10 P00742 1/20 0.31
▸ FPR2 P25090 2/20 0.31
▸ MME P08473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459540 1.00 F2 (0.33) F2PRCPPLGPLAUF10
SCHEMBL17539188 0.96 F2 (0.33) F2PRCPPLGPLAUF10
SCHEMBL22167333 0.96 F2 (0.33) F2PRCPPLGPLAUF10
SCHEMBL17492938 0.96 F2 (0.34) F2PRCPPLGPLAUF10
SCHEMBL17492937 0.96 F2 (0.34) F2PRCPPLGPLAUF10
SCHEMBL22167188 0.96 F2 (0.31) F2
SCHEMBL17459563 0.96 F2 (0.31) F2
SCHEMBL17492907 0.96 F2 (0.31) F2
SCHEMBL17532365 0.93 PRCP (0.32) F2PRCPPLGPLAUF10
SCHEMBL22167416 0.92 F2 (0.32) F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3172199-B1 PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS CELGENE INT II SARL (CH) 2020-07-01 — — EP disclosed
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