Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.31 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17532301 | 1.00 | F2 (0.31) | F2PYGLITGB1ITGA4ITGB7 | |
| SCHEMBL22167489 | 0.94 | S1PR4 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL19181503 | 0.94 | S1PR4 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL17492910 | 0.94 | S1PR4 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL17492911 | 0.94 | S1PR4 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL17532290 | 0.93 | PYGL (0.33) | PYGLMAPK14S1PR1S1PR5DDR1 | |
| SCHEMBL22167480 | 0.92 | S1PR1 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL22167228 | 0.92 | S1PR4 (0.35) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL17532291 | 0.92 | S1PR1 (0.36) | PYGLMAPK14S1PR4S1PR1S1PR5 | |
| SCHEMBL17532289 | 0.92 | S1PR4 (0.35) | PYGLMAPK14S1PR4S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |