Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | GIPR | P48546 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20026814 | 0.87 | PYGL (0.34) | GCGRGIPRPYGLNPC1CYP2C19 | |
| SCHEMBL22167469 | 0.87 | S1PR1 (0.36) | S1PR4S1PR1S1PR5S1PR3GCGR | |
| SCHEMBL17459571 | 0.86 | S1PR4 (0.45) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL17459568 | 0.86 | S1PR4 (0.45) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL17539170 | 0.84 | S1PR4 (0.35) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL19181503 | 0.83 | S1PR4 (0.36) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL22167489 | 0.83 | S1PR4 (0.36) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL17492911 | 0.83 | S1PR4 (0.36) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL17492910 | 0.83 | S1PR4 (0.36) | S1PR4S1PR1S1PR5S1PR3PYGL | |
| SCHEMBL22167468 | 0.83 | PYGL (0.35) | S1PR4S1PR1S1PR5S1PR3PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |