Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | C3AR1 | Q16581 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20026814 | 0.89 | PYGL (0.34) | PYGLNPC1ITGA4ITGB7ITGB1 | |
| SCHEMBL17532353 | 0.85 | F2 (0.32) | PYGLPLGPLAUF10C3AR1 | |
| SCHEMBL17532288 | 0.84 | PYGL (0.31) | PYGLC3AR1S1PR4S1PR1S1PR3 | |
| SCHEMBL22167469 | 0.84 | S1PR1 (0.36) | PYGLS1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL22167407 | 0.83 | S1PR4 (0.39) | PYGLNPC1S1PR4S1PR1S1PR3 | |
| SCHEMBL17834435 | 0.81 | S1PR1 (0.34) | PYGLPLGPLAUF10C3AR1 | |
| SCHEMBL17532306 | 0.80 | PYGL (0.33) | PYGLPLGPLAUF10NPC1 | |
| SCHEMBL17834938 | 0.80 | KIFC1 (0.36) | PYGLC3AR1S1PR4S1PR1S1PR3 | |
| SCHEMBL20026803 | 0.80 | PRCP (0.32) | PYGLPLGPLAUF10NPC1 | |
| SCHEMBL17532336 | 0.80 | PRCP (0.32) | PYGLPLGPLAUF10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |