Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214450 | 0.89 | MAPK14 (0.46) | MAPK14MAPK11CYP3A4CYP2C9SSTR5 | |
| SCHEMBL2215104 | 0.87 | MAPK14 (0.46) | MAPK14MAPK11CYP3A4CYP2C9SSTR5 | |
| SCHEMBL1382659 | 0.85 | MAPK14 (0.50) | MAPK14MAPK11CYP3A4CYP2C9HSD17B10 | |
| SCHEMBL2220451 | 0.83 | MAPK14 (0.48) | MAPK14MAPK11CYP3A4CYP2C9SSTR5 | |
| SCHEMBL11965680 | 0.80 | MAPK14 (0.55) | MAPK14MAPK11CYP3A4CYP2C9HPGD | |
| SCHEMBL11982571 | 0.79 | MAPK14 (0.48) | MAPK14MAPK11CYP3A4CYP2C9SSTR5 | |
| SCHEMBL11965677 | 0.79 | MAPK14 (0.54) | MAPK14MAPK11CYP3A4CYP2C9HPGD | |
| SCHEMBL2218015 | 0.79 | LMNA (0.45) | MAPK14 | |
| SCHEMBL1385810 | 0.78 | MAPK14 (0.47) | MAPK14MAPK11CYP3A4CYP2C9HSD17B10 | |
| SCHEMBL2212815 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |