Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22169181 | 0.80 | TDP1 (0.44) | KMT2AMEN1ALDH1A1CTSDTDP1 | |
| SCHEMBL22169133 | 0.80 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1CTSDTDP1 | |
| SCHEMBL11969154 | 0.80 | MEN1 (0.56) | KMT2AMEN1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL22169096 | 0.77 | ALDH1A1 (0.41) | KMT2AMEN1ALDH1A1CTSDTDP1 | |
| SCHEMBL31231922 | 0.74 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7869240 | 0.73 | ALDH1A1 (0.57) | ALDH1A1CTSDTDP1MAPTRAB9A | |
| SCHEMBL22169234 | 0.73 | TDP1 (0.57) | KMT2AMEN1ALDH1A1CTSDTDP1 | |
| SCHEMBL24621688 | 0.72 | MEN1 (0.49) | KMT2AMEN1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL30395967 | 0.72 | MEN1 (0.49) | KMT2AMEN1ALDH1A1TDP1SMN1; SMN2 | |
| Hydrazobenzene SCHEMBL51179 | 0.72 | ALDH1A1 (1.00) | KMT2AMEN1ALDH1A1CTSDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | IDH1, IDH3B, IDH3A | KMT2A 221/4885MEN1 81/4885ALDH1A1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.