SCHEMBL22172016

SCHEMBL22172016

O=c1c2ccccc2oc2ccc(-c3cccnc3)cc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
CYP19A1 P11511 3/20 0.52
PGR P06401 1/20 0.52
MAOA P21397 4/20 0.51
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 2/20 0.51
GLA P06280 1/20 0.51
CYP3A4 P08684 1/20 0.51
MAPT P10636 1/20 0.51
HPGD P15428 1/20 0.51
PGAM1 P18669 1/20 0.51
CASP1 P29466 1/20 0.51
CASP7 P55210 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HSD17B10 Q99714 1/20 0.51
PIM1 P11309 1/20 0.48
PIM2 Q9P1W9 1/20 0.48
TTR P02766 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650111 0.90 PGR (0.52) CASP3SENP7SENP6CYP19A1PGR
SCHEMBL7920867 0.89 CYP19A1 (0.52) CASP3SENP7SENP6CYP19A1PGR
SCHEMBL23331717 0.87 CYP11B1 (0.50) CYP19A1PGRKDM4EALDH1A1CYP3A4
SCHEMBL22650113 0.87 PGR (0.49) CASP3SENP7SENP6CYP19A1PGR
SCHEMBL14733823 0.85 CYP1A2 (0.56) CYP19A1PGRALDH1A1CYP3A4MAPT
SCHEMBL12608739 0.84 MAOA (0.72) CASP3SENP7SENP6MAOAKDM4E
SCHEMBL24493203 0.84 PGR (0.53) CYP19A1PGRKDM4EALDH1A1CYP3A4
SCHEMBL26936207 0.84 PGR (0.48) CYP19A1PGRKDM4ECYP3A4MAPT
SCHEMBL18928168 0.84 CYP11B1 (0.50) CYP19A1PGRKDM4EALDH1A1CYP3A4
SCHEMBL4572501 0.83 MAOA (0.64) CASP3SENP7SENP6MAOAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020135686-A1 ORGANIC COMPOUND WITH CARBAZOLE DERIVATIVE AS CORE AND APPLICATION THEREOF TO ORGANIC ELECTROLUMINESCENT DEVICE 江苏三月光电科技有限公司 2020-07-02 WO disclosed