Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8749237 | 0.96 | CYP2A6 (0.61) | CYP2A6CYP1A2HSD17B1HSD17B2APP | |
| SCHEMBL29447161 | 0.84 | CYP1A2 (0.79) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL443070 | 0.84 | CYP1A2 (0.79) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL7452675 | 0.79 | CYP1A2 (0.71) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL7451812 | 0.79 | CYP1A2 (0.71) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL29367032 | 0.79 | CYP2A6 (0.80) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL6891918 | 0.79 | CYP1A2 (0.71) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL443528 | 0.79 | CYP2A6 (0.80) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL2249185 | 0.79 | CYP1A2 (0.71) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E | |
| SCHEMBL7456084 | 0.79 | CYP1A2 (0.71) | CYP2A6CYP1A2HSD17B1HSD17B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704558-B | Method for preparing phenyl-2- (2' -cyanophenyl) acetylene compounds by palladium catalysis | 浙江农林大学暨阳学院 | 2023-05-30 | — | — | CN | disclosed |
| CN-111704558-A | Method for preparing phenyl-2- (2' -cyanophenyl) acetylene compounds by palladium catalysis | 浙江农林大学暨阳学院 | 2020-09-25 | — | — | CN | disclosed |
| EP-2872490-B1 | ANTIPROLIFERATIVE BENZO[B]AZEPIN-2-ONES | HOFFMANN LA ROCHE (CH) | 2018-02-07 | — | — | EP | disclosed |
| US-9611224-B2 | Antiproliferative benzo [B] azepin-2-ones | HOFFMANN-LA ROCHE INC. (US) | 2017-04-04 | — | — | US | disclosed |
| WO-2016131098-A1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | THE UNIVERSITY OF QUEENSLAND (AU) | 2016-08-25 | — | — | WO | disclosed |
| US-20150353499-A1 | ANTIPROLIFERATIVE BENZO [B] AZEPIN-2-ONES | HOFFMAN-LA ROCHE INC. (US) | 2015-12-10 | — | — | US | disclosed |
| EP-2872490-A1 | ANTIPROLIFERATIVE BENZO [B]AZEPIN- 2 - ONES | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009495-A1 | ANTIPROLIFERATIVE BENZO [B] AZEPIN- 2 - ONES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |
| US-8455563-B2 | Reactive mesogenic compounds and mixtures | MERCK PATENT GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-8455563-B2 | Reactive mesogenic compounds and mixtures | MERCK PATENT GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| WO-2002024619-A1 | AMINE COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |
| EP-0668259-A1 | A method for the preparation of optically active 2-aryl alkyl aldehydes and formation of 2-aryl-alkanoic acids therefrom | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1995-08-23 | — | — | EP | disclosed |
| US-5434302-A | Method for the preparation of optically active 2-aryl alkyl aldehydes and formation of 2-aryl-alkanoic acids therefrom | PARADIES H HENRICH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| US-4723033-A | REACTING ALPHA METAL ACID DERIVATIVE AND ARYL HALIDE WITH OPTICALLY ACTIVE CATALYST | SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) | 1988-02-02 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0110671-B1 | PREPARATION OF OPTICALLY ACTIVE ALPHA-ARYLALKANOIC ACIDS AND PRECURSORS THEREOF | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1986-05-21 | — | — | EP | disclosed |
| EP-0110671-A1 | Preparation of optically active alpha-arylalkanoic acids and precursors thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1984-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353499-A1 | ANTIPROLIFERATIVE BENZO [B] AZEPIN-2-ONES | CCNY, RB1, TOP2B | CYP2A6 3509/4885CYP1A2 2008/4885HSD17B1 2864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.