Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20509598 | 0.88 | FFAR4 (0.64) | PKMFFAR4PTGDR2POLBSMN1; SMN2 | |
| SCHEMBL25337583 | 0.88 | ALDH1A1 (0.54) | PKMFFAR4PTGDR2SMN1; SMN2L3MBTL1 | |
| SCHEMBL29116901 | 0.85 | ALDH1A1 (0.44) | PKMFFAR4SMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL718460 | 0.84 | PTGDR2 (0.68) | PKMPTGDR2CYSLTR1POLBSMN1; SMN2 | |
| SCHEMBL22164183 | 0.84 | PKM (0.55) | PKMPTGDR2CYSLTR1POLBSMN1; SMN2 | |
| SCHEMBL4138843 | 0.84 | PKM (0.71) | PKMPTGDR2CYSLTR1POLBSMN1; SMN2 | |
| SCHEMBL2610714 | 0.83 | CHEK1 (0.47) | FFAR4SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL29117002 | 0.83 | FFAR4 (0.42) | PKMFFAR4SMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL29116910 | 0.83 | ALDH1A1 (0.43) | PKMFFAR4SMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL18914159 | 0.82 | MAPT (0.48) | FFAR4SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |