SCHEMBL22180508

SCHEMBL22180508

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nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.48
SLCO1B1 Q9Y6L6 1/20 0.48
TDP1 Q9NUW8 2/20 0.33
PDE4A P27815 1/20 0.32
SLC7A5 Q01650 1/20 0.32
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NOS2 P35228 2/20 0.32
TRPV1 Q8NER1 1/20 0.30
PAX8 Q06710 1/20 0.30
TRPA1 O75762 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11274631 0.83
SCHEMBL20133522 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ALMNA
SCHEMBL4330349 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ALMNA
SCHEMBL107892 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ALMNA
SCHEMBL23097183 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ASLC7A5
SCHEMBL585124 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ASLC7A5
SCHEMBL22760260 0.82 USP2 (0.48) USP2SLCO1B1TDP1PDE4ASLC7A5
SCHEMBL19681574 0.82 USP2 (0.48) USP2SLCO1B1TDP1PDE4ASLC7A5
SCHEMBL587181 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ASLC7A5
SCHEMBL15423731 0.82 USP2 (0.65) USP2SLCO1B1TDP1PDE4ASLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200207859-A1 METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA SUTRO BIOPHARMA, INC. 2020-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200207859-A1 METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN TREATMENT OF T-CELL LYMPHOMA CD74, CD99, CD2 USP2 1833/4885SLCO1B1 2031/4885TDP1 1768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.