SCHEMBL22181027

SCHEMBL22181027

CCCCc1nc2c(N)nc3ccccc3c2n1CCCCNC(=O)CCOCCOCCNC(=O)CCN1C(=O)CC(SCC(=O)NC)C1=O

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.53
TLR8 Q9NR97 12/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20801435 0.96 TLR7 (0.53) TLR7TLR8
SCHEMBL20801431 0.96 TLR7 (0.53) TLR7TLR8
SCHEMBL24409517 0.92 TLR7 (0.54) TLR7TLR8
SCHEMBL20801489 0.92 TLR7 (0.50) TLR7TLR8
SCHEMBL24860012 0.90 TLR7 (0.52) TLR7TLR8
SCHEMBL22180957 0.89 TLR7 (0.48) TLR7TLR8
SCHEMBL24859968 0.89 TLR7 (0.56) TLR7TLR8
SCHEMBL20801443 0.89 TLR7 (0.56) TLR7TLR8
SCHEMBL22181147 0.85 TLR7 (0.55) TLR7TLR8
SCHEMBL20801527 0.84 TLR7 (0.61) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11110178-B2 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY (US) 2021-09-07 US disclosed
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES BOLT BIOTHERAPEUTICS, INC. 2020-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885
US-11110178-B2 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.