Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.40 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22182063 | 0.85 | DNMT1 (0.38) | DNMT1DNMT3LDNMT3AMEN1KMT2A | |
| SCHEMBL22182009 | 0.85 | MEN1 (0.34) | DNMT1DNMT3LDNMT3AMEN1KMT2A | |
| SCHEMBL22182092 | 0.79 | HDAC3 (0.52) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL22181900 | 0.75 | MEN1 (0.39) | DNMT1DNMT3LDNMT3AMEN1KMT2A | |
| SCHEMBL22181927 | 0.74 | MEN1 (0.38) | DNMT1DNMT3LDNMT3AMEN1KMT2A | |
| SCHEMBL22181897 | 0.73 | MEN1 (0.33) | MEN1KMT2APOLBCASP1MAPT | |
| SCHEMBL22181867 | 0.72 | HEXA (0.47) | MEN1KMT2APOLBCASP1MAPT | |
| SCHEMBL22182021 | 0.70 | HDAC3 (0.50) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL22181998 | 0.67 | SIRT1 (0.53) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL22181899 | 0.67 | MEN1 (0.56) | MEN1KMT2APOLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |