Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL9216454 | 0.84 | TSHR (0.35) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL5859117 | 0.82 | TSHR (0.53) | TSHRTRPA1ALDH1A1NAPRTTDP1 | |
| Pyrimidine SCHEMBL27526411 | 0.77 | — | — | |
| Pyrimidine SCHEMBL19876786 | 0.77 | TSHR (0.40) | TSHRNAPRTTDP1 | |
| Pyrimidine SCHEMBL8355332 | 0.75 | — | — | |
| Pyrimidine SCHEMBL3709916 | 0.75 | — | — | |
| Pyrimidine SCHEMBL27645497 | 0.75 | — | — | |
| Pyrimidine SCHEMBL3163212 | 0.75 | — | — | |
| Pyrimidine SCHEMBL3705061 | 0.75 | — | — | |
| Pyrimidine SCHEMBL27891987 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394956-B2 | Process for preparing pyrimidine propenaldehyde | AUROBINDO PHARMA LTD. (IN) | 2013-03-12 | — | — | US | disclosed |
| EP-2350025-A1 | AN IMPROVED PROCESS FOR PREPARING PYRIMIDINE PROPENALDEHYDE | Aurobindo Pharma Limited (IN) | 2011-08-03 | — | — | EP | disclosed |
| US-20110178296-A1 | Process for preparing pyrimidine propenaldehyde | MALLELA SAMBHU PRASAD SARMA | 2011-07-21 | — | — | US | disclosed |
| WO-2010038124-A1 | AN IMPROVED PROCESS FOR PREPARING PYRIMIDINE PROPENALDEHYDE | AUROBINDO PHARMA LIMITED (IN) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178296-A1 | Process for preparing pyrimidine propenaldehyde | DPYD, NOX4, RPIA | TSHR 4380/4885TRPA1 2216/4885ALDH1A1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.