Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 6/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252333 | 0.73 | GSK3B (0.48) | GSK3BDYRK1AALDH1A1CYP3A4TSHR | |
| SCHEMBL2086344 | 0.73 | DYRK1A (0.66) | GSK3BDYRK1A | |
| SCHEMBL2088884 | 0.73 | DYRK1A (0.56) | GSK3BDYRK1AALDH1A1CYP3A4TSHR | |
| SCHEMBL2086317 | 0.72 | HTR4 (0.38) | PIK3CAMTORALDH1A1CYP3A4TSHR | |
| SCHEMBL12515208 | 0.72 | HTR4 (0.38) | GSK3BDYRK1APIK3CAMTORALDH1A1 | |
| SCHEMBL12843957 | 0.72 | HTR4 (0.38) | GSK3BDYRK1APIK3CAMTORALDH1A1 | |
| SCHEMBL13945574 | 0.72 | HTR4 (0.38) | GSK3BDYRK1APIK3CAMTORALDH1A1 | |
| SCHEMBL12515207 | 0.72 | HTR4 (0.38) | GSK3BDYRK1APIK3CAMTORALDH1A1 | |
| SCHEMBL2088552 | 0.70 | DYRK1A (0.62) | GSK3BDYRK1A | |
| SCHEMBL2087356 | 0.70 | DYRK1A (0.62) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | GSK3B 920/4885DYRK1A 1558/4885PIK3CA 3467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.