SCHEMBL221885

SCHEMBL221885

Cc1c(F)ccc(C#N)c1C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 16/20 0.58
PGR P06401 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13216378 0.86 AR (0.64) AR
SCHEMBL12812528 0.82 AR (0.60) ARPGR
SCHEMBL25330095 0.80 AR (0.45) ARPGR
SCHEMBL31131413 0.80 AR (0.45) ARPGR
SCHEMBL324996 0.79 AR (0.57) AR
SCHEMBL1291612 0.79 AR (0.57) ARPGR
SCHEMBL2693449 0.77 AR (0.47) AR
SCHEMBL24508330 0.77 AR (0.50) ARPGR
SCHEMBL15421833 0.77 AR (0.42) ARPGR
SCHEMBL17806029 0.77 AR (0.32) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023139199-A1 COMPOUNDS AND THEIR USE IN TREATING CANCER ASTRAZENECA AB (SE) 2023-07-27 WO disclosed
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 US disclosed
US-11001556-B2 Crystalline forms GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2021-05-11 US disclosed
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2020-11-19 US disclosed
US-20200308113-A1 CRYSTALLINE FORMS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2020-10-01 US disclosed
US-20200270210-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED 2020-08-27 US disclosed
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2020-08-04 US disclosed
US-10562852-B2 Crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2020-02-18 US disclosed
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-02-07 US disclosed
US-10196353-B2 Chemical compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED (GB) 2019-02-05 US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US disclosed
EP-2222636-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF Ligand Pharmaceuticals Inc. (US) 2010-09-01 EP disclosed
WO-2009082437-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2010-08-12 WO disclosed
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2010-02-18 US disclosed
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2010-02-18 US disclosed
US-20090253758-A1 Selective androgen receptor modulators ELLIPSES PHARMA LTD (GB) 2009-10-08 US disclosed
US-20090253758-A1 Selective androgen receptor modulators ELLIPSES PHARMA LTD (GB) 2009-10-08 US disclosed
WO-2009105214-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2009-08-27 WO disclosed
WO-2009105214-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS RADIUS HEALTH, INC. (US) 2009-08-27 WO disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041721-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS AR, SHBG, IGF1R AR 1/4885PGR 16/4885
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885PGR 92/4885
US-20200270210-A1 CHEMICAL COMPOUNDS AR, NR5A1, ESRRA AR 1/4885PGR 49/4885
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885PGR 97/4885
US-11001556-B2 Crystalline forms SHBG, NR5A1, AR AR 3/4885PGR 177/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885PGR 82/4885
US-20200308113-A1 CRYSTALLINE FORMS SHBG, NR5A1, AR AR 3/4885PGR 177/4885
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885PGR 92/4885
US-10196353-B2 Chemical compounds AR, NR5A1, ESRRA AR 1/4885PGR 49/4885
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885PGR 82/4885
US-20090253758-A1 Selective androgen receptor modulators AR, SHBG, GPR119 AR 1/4885PGR 28/4885
US-10562852-B2 Crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile AR, NR5A1, SHBG AR 1/4885PGR 119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.