Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 15/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086702 | 0.84 | DYRK1A (0.54) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2086700 | 0.84 | DYRK1A (0.54) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2087492 | 0.79 | DYRK1A (0.55) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2088278 | 0.79 | DYRK1A (0.63) | GSK3BDYRK1A | |
| SCHEMBL2087246 | 0.79 | DYRK1A (0.63) | GSK3BDYRK1A | |
| SCHEMBL2086418 | 0.78 | GSK3B (0.56) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2086417 | 0.78 | GSK3B (0.56) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL12441864 | 0.78 | GSK3B (0.56) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2086192 | 0.77 | HTR3A (0.68) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 | |
| SCHEMBL2086190 | 0.77 | HTR3A (0.68) | GSK3BDYRK1AHTR3AHTR3ESLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | GSK3B 920/4885DYRK1A 1558/4885HTR3A 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.