Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26832626 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL24031696 | 0.82 | EZH2 (0.42) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL24233212 | 0.81 | OGG1 (0.46) | RAB9ANPC1LMNAMEN1KMT2A | |
| SCHEMBL22047564 | 0.80 | DDB1 (0.45) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL24031980 | 0.79 | NPC1 (0.50) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL25059051 | 0.79 | CHRNA7 (0.39) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL24193083 | 0.79 | ACACB (0.40) | SMN1; SMN2RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL22047308 | 0.78 | CHRNA7 (0.38) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL105169 | 0.77 | RAB9A (0.57) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL8738667 | 0.75 | EZH2 (0.67) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |