Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13313003 | 0.85 | LMNA (0.66) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL26100801 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL4230856 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL1774454 | 0.81 | LMNA (0.66) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL4233865 | 0.80 | LMNA (0.52) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23068261 | 0.80 | LMNA (0.64) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL9464633 | 0.79 | LMNA (0.63) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL4056059 | 0.79 | LMNA (0.58) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL23453748 | 0.78 | MEN1 (0.57) | MEN1KMT2ALMNA | |
| SCHEMBL4064130 | 0.77 | MEN1 (1.00) | MEN1KMT2ALMNAARP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |