Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200391 | 0.94 | ERN1 (0.35) | ERN1TSHRHTTBTKMAPT | |
| SCHEMBL22200559 | 0.90 | ERN1 (0.40) | ERN1TSHRHTTBTKSRC | |
| SCHEMBL29356139 | 0.85 | ERN1 (0.49) | ERN1ALOX5APFEN1 | |
| SCHEMBL22190892 | 0.85 | ERN1 (0.49) | ERN1ALOX5APFEN1 | |
| SCHEMBL22200440 | 0.85 | ALDH1A1 (0.42) | ERN1TSHRHTTBTKSRC | |
| SCHEMBL22200407 | 0.84 | ERN1 (0.40) | ERN1BTKMAPTRXFP1PIK3CA | |
| SCHEMBL22200564 | 0.83 | ERN1 (0.39) | ERN1TSHRHTTBTKMAPT | |
| SCHEMBL22200758 | 0.83 | BRAF (0.39) | ERN1TSHRHTTSRCABL1 | |
| SCHEMBL22190691 | 0.80 | ERN1 (0.44) | ERN1ALOX5APFEN1 | |
| SCHEMBL29354823 | 0.80 | ERN1 (0.44) | ERN1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |