Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 2/20 | 0.37 |
| ▸ | STK3 | Q13188 | 2/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.37 |
| ▸ | STK26 | Q9P289 | 2/20 | 0.37 |
| ▸ | STK24 | Q9Y6E0 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035557 | 0.85 | BRAF (0.44) | BRAFRIPK2ACVR1NOD2ALOX5AP | |
| SCHEMBL22200559 | 0.84 | ERN1 (0.40) | SRCBTKBRAFALOX5APFEN1 | |
| SCHEMBL22200758 | 0.82 | BRAF (0.39) | SRCBRAFALOX5APFEN1EGFR | |
| SCHEMBL22200440 | 0.79 | ALDH1A1 (0.42) | SRCLYNBTKRIPK2ACVR1 | |
| SCHEMBL25035385 | 0.75 | BRAF (0.45) | SRCBTKBRAFSTK4STK3 | |
| SCHEMBL22200566 | 0.74 | ERN1 (0.40) | SRCLYNBTKALOX5APFEN1 | |
| SCHEMBL22200562 | 0.74 | PIK3CA (0.42) | SRCLYNBTKBRAFPIK3CA | |
| SCHEMBL22200391 | 0.72 | ERN1 (0.35) | SRCBTKBRAFALOX5APFEN1 | |
| SCHEMBL22200366 | 0.72 | ERN1 (0.47) | SRCBTKBRAFPIK3CAEGFR | |
| SCHEMBL22200725 | 0.69 | BTK (0.38) | SRCBTKBRAFPIK3CAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |