Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201301 | 0.92 | PDE5A (0.47) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201412 | 0.84 | TGFBR1 (0.65) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201672 | 0.83 | HPGD (0.64) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201247 | 0.82 | GRM4 (0.50) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201264 | 0.80 | ABCG2 (0.71) | PDE5AABCG2ABCB1MAPTLMNA | |
| SCHEMBL22201303 | 0.80 | PDE5A (0.46) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201300 | 0.80 | TGFBR1 (0.52) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201407 | 0.79 | TGFBR1 (0.60) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201253 | 0.79 | PDE5A (0.47) | TGFBR1PDE5AABCG2ABCB1ABCC1 | |
| SCHEMBL22201372 | 0.78 | PDE5A (0.46) | TGFBR1PDE5AABCG2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |