Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 15/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | CD38 | P28907 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201247 | 0.81 | GRM4 (0.50) | ABCG2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL22201412 | 0.81 | TGFBR1 (0.65) | ABCG2ALDH1A1LMNAHPGDCD38 | |
| SCHEMBL22201407 | 0.80 | TGFBR1 (0.60) | ABCG2ALDH1A1LMNAHPGDCD38 | |
| SCHEMBL22201301 | 0.80 | PDE5A (0.47) | ABCG2ALDH1A1LMNAHPGDPDE5A | |
| SCHEMBL22201253 | 0.80 | PDE5A (0.47) | ABCG2ALDH1A1LMNAHPGDPDE5A | |
| SCHEMBL22201291 | 0.80 | TGFBR1 (0.48) | ABCG2ALDH1A1LMNAHPGDPDE5A | |
| SCHEMBL22201289 | 0.80 | ABCG2 (0.79) | ABCG2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL22201263 | 0.79 | TGFBR1 (0.61) | ABCG2ALDH1A1LMNAHPGDPDE5A | |
| SCHEMBL22201274 | 0.79 | TGFBR1 (0.63) | ABCG2PDE5AEGFR | |
| SCHEMBL22201300 | 0.79 | TGFBR1 (0.52) | ABCG2ALDH1A1LMNAHPGDPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |