Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 4/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201332 | 0.81 | PGR (0.64) | PGRSMN1; SMN2POLBTSHR | |
| SCHEMBL9649977 | 0.73 | MAPT (0.48) | MAPTSMN1; SMN2TSHRTP53 | |
| SCHEMBL15142775 | 0.73 | POLB (0.59) | POLB | |
| SCHEMBL28128590 | 0.70 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL24031105 | 0.69 | HDAC1 (0.70) | PGRTP53 | |
| SCHEMBL3800114 | 0.69 | CXCR4 (0.54) | TP53NPSR1TDP1 | |
| SCHEMBL14515145 | 0.68 | CBX7 (0.53) | — | |
| SCHEMBL9776542 | 0.68 | MAPT (0.71) | MAPTKDM4EHSD17B10POLBTSHR | |
| SCHEMBL6362495 | 0.67 | PGR (0.71) | PGRKDM4EHSD17B10POLBTSHR | |
| SCHEMBL5257605 | 0.67 | CYP3A4 (0.50) | SMN1; SMN2KDM4EHSD17B10TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |