Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774821 | 0.96 | ROCK2 (0.71) | ROCK2ROCK1HTR2APKN1PKN2 | |
| SCHEMBL30611459 | 0.96 | ROCK2 (0.71) | ROCK2ROCK1HTR2APKN1PKN2 | |
| SCHEMBL22201290 | 0.89 | PIK3CA (0.65) | ROCK2HTR2ATGFBR1 | |
| SCHEMBL3580823 | 0.89 | ROCK2 (0.64) | ROCK2ROCK1HTR2ATGFBR1 | |
| SCHEMBL3576178 | 0.86 | ROCK2 (0.61) | ROCK2ROCK1HTR2ATGFBR1 | |
| SCHEMBL3582369 | 0.84 | HTR2A (0.67) | ROCK2ROCK1HTR2ATGFBR1 | |
| SCHEMBL3579466 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1HTR2ATGFBR1 | |
| SCHEMBL20774632 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL30611383 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL22126148 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |