Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.65 |
| ▸ | HTR2A | P28223 | 3/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201371 | 0.89 | ROCK2 (0.68) | HTR2AROCK2TGFBR1 | |
| SCHEMBL3580823 | 0.88 | ROCK2 (0.64) | PIK3CAHTR2AROCK2HTR2CTGFBR1 | |
| SCHEMBL20774821 | 0.85 | ROCK2 (0.71) | HTR2AROCK2TGFBR1 | |
| SCHEMBL3576178 | 0.85 | ROCK2 (0.61) | PIK3CAHTR2AROCK2HTR2CTGFBR1 | |
| SCHEMBL30611459 | 0.85 | ROCK2 (0.71) | HTR2AROCK2TGFBR1 | |
| SCHEMBL3582369 | 0.83 | HTR2A (0.67) | HTR2AROCK2HTR2CTGFBR1MAPT | |
| SCHEMBL3579466 | 0.82 | ROCK2 (0.56) | HTR2AROCK2HTR2CTGFBR1 | |
| SCHEMBL22201650 | 0.82 | PIK3CA (0.56) | PIK3CAHTR2AROCK2HTR2CPIK3CD | |
| SCHEMBL3580875 | 0.82 | ROCK2 (0.53) | PIK3CAROCK2TGFBR1 | |
| SCHEMBL1822731 | 0.80 | PIK3CA (0.63) | PIK3CAHTR2AROCK2HTR2CPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |