Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.63 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 16/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062778 | 0.90 | TGFBR1 (0.71) | TGFBR1KDM1APRKD1ABCG2ABCB1 | |
| SCHEMBL22201341 | 0.85 | PRKD1 (0.66) | TGFBR1KDM1APRKD1ABCG2ABCB1 | |
| SCHEMBL22201275 | 0.85 | TGFBR1 (0.64) | TGFBR1ABCG2ABCB1ABCC1 | |
| SCHEMBL22201553 | 0.84 | KDM1A (0.66) | TGFBR1KDM1APRKD1ABCG2MEN1 | |
| SCHEMBL13319617 | 0.80 | MEN1 (0.65) | TGFBR1KDM1APRKD1MEN1KMT2A | |
| SCHEMBL22201330 | 0.79 | TGFBR1 (0.62) | TGFBR1KDM1APRKD1ABCG2MEN1 | |
| SCHEMBL13319635 | 0.78 | ABCG2 (0.56) | TGFBR1KDM1APRKD1ABCG2MEN1 | |
| SCHEMBL13319618 | 0.78 | TGFBR1 (0.64) | TGFBR1KDM1APRKD1ABCG2ABCB1 | |
| SCHEMBL22201263 | 0.78 | TGFBR1 (0.61) | TGFBR1KDM1APRKD1ABCG2ABCB1 | |
| SCHEMBL22201678 | 0.76 | HPGD (0.65) | TGFBR1ABCG2ABCB1ABCC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |